parasites - toxoplasma is making everyone insane?
A good t-shirt. IS toxoplasma making us all insane? That's what some researchers suggest.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14725265&dopt=Citation
# life-cycle in intermediate host (this also occurs in felids)
1. oocysts or tissue cysts ingested
2. sporozoites (from oocysts) or bradyzoites (from tissue cysts) penetrate intestinal wall
3. dissemination throughout body
4. penetrate cells; under endodyogeny as tachyzoites. "Groups" of tachyzoites develop in host cells
5. tachyzoites rupture from cells and initiate new infections
6. eventually, some tachyzoites transform into slower dividing bradyzoites; cyst wall layed down around parasitophorous vacuole derived from both the ER and host cell mitochondria
7. tissue cyst gradually increases in size; bradyzoites increase in number by undergoing slow endodyogeny; metrocytes absent
8. eventually, cysts become dormant; occasionally rupturing and liberating bradyzoites. If immunity has waned, bradyzoites may transform into tachyzoites and increase in numbers. If still immune, bradyzoites destroyed.
# pathology includes no clinical signs to lymphadenopathy, muscle pain, fatigue, birth defects (tachyzoites can cross placenta), abortion, blindness, seizures, and occasionally death
# prevention
1. litter boxes should be changed every 48 hours to keep sporulated oocysts from accumulating
2. all meat should be cooked thoroughly, especially meat fed to cats
3. new cats should not be obtained in households with pregnant females
4. childrens sandboxes should be kept covered when not in use
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14725265&dopt=Citation
# life-cycle in intermediate host (this also occurs in felids)
1. oocysts or tissue cysts ingested
2. sporozoites (from oocysts) or bradyzoites (from tissue cysts) penetrate intestinal wall
3. dissemination throughout body
4. penetrate cells; under endodyogeny as tachyzoites. "Groups" of tachyzoites develop in host cells
5. tachyzoites rupture from cells and initiate new infections
6. eventually, some tachyzoites transform into slower dividing bradyzoites; cyst wall layed down around parasitophorous vacuole derived from both the ER and host cell mitochondria
7. tissue cyst gradually increases in size; bradyzoites increase in number by undergoing slow endodyogeny; metrocytes absent
8. eventually, cysts become dormant; occasionally rupturing and liberating bradyzoites. If immunity has waned, bradyzoites may transform into tachyzoites and increase in numbers. If still immune, bradyzoites destroyed.
# pathology includes no clinical signs to lymphadenopathy, muscle pain, fatigue, birth defects (tachyzoites can cross placenta), abortion, blindness, seizures, and occasionally death
# prevention
1. litter boxes should be changed every 48 hours to keep sporulated oocysts from accumulating
2. all meat should be cooked thoroughly, especially meat fed to cats
3. new cats should not be obtained in households with pregnant females
4. childrens sandboxes should be kept covered when not in use
posted by weltanschuuang at 7:17 PM
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